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Objective: Clinical symptoms of organic brain damage in opium addiction vary from mild to severe disturbances. Pharmacological properties of gliatilin suggest that it may be useful to administer the drug to opiate-dependent patients the stage of remission. The aim of the work was to evaluate the efficacy of gliatilin in the treatment of patients with opiate dependence in the early stages of remission, at 10-14 days cessation of heroin use.
Methods: The study included 60 patients diagnosed according to ICD-10 with “withdrawal from opiate drugs.” Patients of the first group received gliatilin with standard therapy, patients of the second group only standard therapy (hypnotics) ). The total duration of the study in both comparison groups was 2 months. At the beginning and end of the study, the intensity and structure of pathological inclinations was evaluated using the glossary NV Cherednychenko and VB Altshuller. Prior to treatment, almost all patients had symptoms of cognitive deficits of varying severity. Assessment of the dynamics of the exponents and quality concentration was carried out using the Schulte table. When applying gliatilin, in the first group of heroin addicts after 7 days of treatment there was a decrease run-time jobs.
Results: When analyzing the dynamics of quantitative indicators of attention on the Kraepelin table, most significant improvement was noted in patients taking gliatilin. By the end of therapy, the number of memorized words reached 10.09±4.2. Improvement was observed also in the 2nd group of patients, but it was less pronounced: Dynamics of qualitative indicators of attention was also more pronounced with the application of gliatilin. In group 1, at the end of therapy, the number of errors decreased by 58% in group 2 by 32%. Statistically significant differences in terms of short-term memory between the groups of patients were already seen after 21 days of therapy. In assessing the dynamics of long-term memory, the two groups also experienced improvement in reproducing words. The most pronounced improvement was noted in group 1: at the end of therapy, an increase in number of reproduced words by 34% compared to the background. In group 2, an increase in the number of words compared to the background was much less pronounced. In the nature of the reduction of craving for the drug (CD) significant differences were found between the two groups. As a result in the first group, the expression of all components of the autonomic component CD was significantly lower than in the second group.
Conclusion: Using gliatilin leads to a significant improvement in cognitive functioning in patients with restoration of quantitative and qualitative indicators of attention, short-term and long-term memory. Introduction gliatilin the complex pharmacotherapy was not accompanied by adverse events, which makes gliatilin effective and safe in the initial therapeutic remission with heroin addiction.