Psychiatry and Clinical Psychopharmacology
ORIGINAL ARTICLE

A Cross-Sectional Measurement of Endogenous Oxidative Stress Marker Levels in Obsessive Compulsive Disorder

1.

Department of Pyschiatry, Van Yüzüncü Yıl University, School of Medicine, Van, Turkey

2.

Department of Psychiatry, Ankara Bilkent City Hospital, Ankara, Turkey

3.

Department of Medicine Biochemistry, Van Yüzüncü Yıl University, Van, Turkey

4.

Clinic of Psychiatry, Florence Nightingale Hospital, İstanbul, Turkey

5.

Department of Psychiatry, Dicle University, School of Medicine, Diyarbakır, Turkey

Psychiatry and Clinical Psychopharmacology 2022; 32: 215-221
DOI: 10.5152/pcp.2022.21162
Read: 371 Downloads: 53 Published: 01 September 2022

Background: There is a correlation between the increase in reactive oxygen radicals and the presence of specific mental illnesses. In this context, the objective of this study is to investigate the relationship between obsessive-compulsive disorder and the variations in the levels of several endogenous oxidative stress markers.

Methods: Thirty obsessive-compulsive disorder patients were included in the study as the patient group, and 30 healthy volunteers of matching demographic characteristics were included in the study as the control group. Accordingly, the patient group consisted of 10 females and 20 males with a mean age of 29.5 ± 6.1 years, and the control group consisted of 15 females and 15 males with a mean age of 31.9±5.6 years. The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were compared using the independent samples t-test. The relationships between the serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the 2 groups were analyzed using the Pearson’s correlation coefficient.

Results: The serum nicotinamide adenine dinucleotide phosphate oxidase-2, nicotinamide adenine dinucleotide phosphate oxidase-4, and malondialdehyde levels of the patient group were statistically significantly higher than those of the control group (P < .001). Statistically significant positive correlations were detected between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and nicotinamide adenine dinucleotide phosphate oxidase-4 levels (r=0.692, P=.001) and between the serum nicotinamide adenine dinucleotide phosphate oxidase-2 and malondialdehyde levels (r=0.563, P=.001).

Conclusion: The results of this study indicated that oxidative stress and lipid peroxidation levels were higher in obsessive-compulsive disorder patients. Based on this finding, NOX-2 and NOX-4 levels can be used as indicators of endogenous oxidative stress in obsessive-compulsive disorder patients.

Cite this article as: Kurhan F, Kamış GZ, Alp HH, Akyüz Çim EF, Atlı A. A cross-sectional measurement of endogenous oxidative stress marker levels in obsessive compulsive disorder. Psychiatry Clin Psychopharmacol. 2022;32(3):215-221.

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