Bipolar disorder is a major mood disorder characterized by manic, depressive, and mixed episodes and affecting an estimated 1–3% of the population. Ethio-pathogenesis of the disorder not clear yet. Biomarker reliability of oxidative stress markers in bipolar disorder has not been revealed. There are many reports that supports the idea of oxidative stress markers might have a role in the pathophysiology of bipolar disorder. Results of the studies about the antioxidant enzyme levels performed in bipolar patients were not constant enough to make a conclusion about this topic. In this presentation we will discuss the therapeutic interventions and oxidative stress markers in bipolar disorder.