Psychiatry and Clinical Psychopharmacology
REVIEW

The Use of Tamoxifen as a Potential Treatment for Bipolar Disorder

1.

Department of Microbiology, Immunology and Genetics, Ben-Gurion University of the Negev, Israel

2.

Department of Clinical Biochemistry and Pharmacology, Ben-Gurion University of the Negev, Israel

3.

Department of Nursing, Ben-Gurion University of the Negev, Israel

Psychiatry and Clinical Psychopharmacology 2021; 31: 344-352
DOI: 10.5152/pcp.2021.21817
Read: 114 Downloads: 45 Published: 14 July 2021

Bipolar disorder (BD) is a chronic mental disease that substantially affects the patient’s quality of life and causes significant morbidity and mortality. Although there are a variety of available treatments, therapeutic intervention is not beneficial in many cases and recurrence rates remain high. Recent data suggested tamoxifen, a drug with a wide range of activities, as a potential treatment for reducing manic symptoms of BD. Tamoxifen’s therapeutic effect on bipolar mania has not been fully elucidated, but it is believed to biochemically operate on protein kinase C (PKC) inhibition. In this article, we review preclinical and clinical studies investigating the efficacy of tamoxifen as a potential treatment for bipolar manic patients.

Cite this article as: Bagdadi N, Azab AN, Shvartsur R. The use of tamoxifen as a potential treatment for bipolar disorder. Psychiatr Clin Psychopharmacol. 2021;31(3):344-352.

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