Psychiatry and Clinical Psychopharmacology
Original Article

The Relationship of Plasma Transthyretin Level with Global or Regional Amyloid Beta Burden in Subjects with Amnestic Mild Cognitive Impairment: Cross-Sectional Amyloid PET Study

1.

Department of Psychiatry, Pusan National University School of Medicine, Busan, Republic of Korea

2.

Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea

3.

Department of Radiology, Pusan National University School of Medicine, Busan, Republic of Korea

4.

Department of Nuclear Medicine, Pusan National University School of Medicine, Busan, Republic of Korea

5.

Department of Pathology, Pusan National University School of Medicine, Busan, Republic of Korea

Psychiatry and Clinical Psychopharmacology 2022; 32: 4-8
DOI: 10.5152/pcp.2022.21206
Read: 1650 Downloads: 178 Published: 01 March 2022

Background: To investigate the relationships of plasma transthyretin levels with amyloid beta deposition and medial temporal atrophy in amnestic mild cognitive impairment.

Methods: This is a cross-sectional study of association of subjects with amnestic mild cognitive impairment. Plasma transthyretin levels, brain magnetic resonance imaging, and 18F-florbetaben positron emission tomography were simultaneously measured in subjects with amnestic mild cognitive impairment.

Results: Plasma transthyretin levels were positively associated with amyloid beta deposition in global (r=0.394, P=.009), frontal cortex (r=0.316, P=.039), parietal cortex (r=0.346, P=.023), temporal cortex (r=0.372, P=.014), occipital cortex (r=0.310, P=.043), right posterior cingulate (r=0.350, P=.021), left precuneus (r=0.314, P=.040), and right precuneus (r=0.398, P=.008). No association between plasma transthyretin level and medial temporal sub-regional atrophies was found.

Conclusions: Our findings of positive association of plasma transthyretin levels with global and regional amyloid beta burden suggest upregulation of transthyretin level as a reactive response to amyloid beta deposition during the early stages of the Alzheimer’s disease process.

Cite this article as: Lee K, Lee Y-M, Park J-M, et al. The relationship of plasma transthyretin level with global or regional amyloid beta burden in subjects with amnestic mild cognitive impairment: cross-sectional amyloid PET study. Psychiatr Clin Psychopharmacol. 2022;32(1):4-8.

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