.png)
Tinnitus is defined as the perceived sensation of sound without an external acoustic stimulus. Tinnitus sensations are usually of an unformed acoustic nature such as a hissing, ringing, whistling, or buzzing. It is not a disorder and it is a symptom with an incidence increasing with age. Although objective tinnitus has multiple possible causes such as (auto toxicity, vascular changes, cerumen, auto sclerosis, otitis media, palatal myoclonus, vestibular schwannoma and other intracranial pathologies etc.), the reasons for subjective tinnitus cannot be detected. Tinnitus is a potentially distressing condition with a wide range of symptoms that can place a huge burden on patients and substantially impair quality of life. It’s well known that up to 70% of tinnitus sufferers might present psychiatric comorbidities. Management of tinnitus includes counseling, cognitive behavioral therapy, sound therapy, hearing aids, cochlear implants, pharmacotherapy, and brain stimulation. Although there is no a drug yet been approved by the international agencies (FDA etc.) for the treatment of tinnitus, some drugs are widely used all over the world such as betahistine, trimetazidine, gingko biloba, gabapentin and cinnarizin. In addition, some antidepressant and anxiolytic agents can also be used in patients with psychiatric comorbid conditions. We present the improvement effect of duloxetine in a 62-year-old female patient with nonpulsatile, subjective, and non-healing tinnitus with betahistine, trimetazidine, gabapentin treatment.