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Encephalitis, one of the central nervous system infections, can coexist with neurological findings such as resistant generalized or complex partial epileptic seizures that develop over a few days or weeks. It can also coexist with psychiatric findings such as memory impairment, various types of affective disorders or behavioral disorders. Memory impairment: recent anterograde and retrograde amnesia; affective disorders: depression, anxiety, emotional liability and personality changes as well as hallucinations and paranoid delusions are common psychiatric symptoms. B.A. is a 12-year-old male, a 6th grade student. No special characteristic has been identified in the patient’s prenatal, natal and postnatal periods. The patient’s infancy and childhood development story is identified as normal. In June 2011, when he was 10 years old, he was taken to the hospital one night due to contraction and foaming mouth. He was taken to EUMF Neurology Department for seizure control and etiology study. The epilepsy is identified to be squeal of viral meningoencephalitis. After observing that GTK seizures occur up to 15 times a day, midazolam infusion was initiated. The seizures came to a halt, and the patient’s treatment proceeded with valproate and carbamazepine. In that period, risperidone treatment was also implemented due to agitation. The seizures were thus under control, and the patient was discharged and taken under policlinic follow-up. When a psychiatric evaluation is carried out after a comparison of the patient’s condition before and after June 2011 based on the information received from the patient himself and his family, changes that seriously affect functionality have been observed in the patient. Based on the present findings, the patient has been diagnosed as having major depression and mental retardation. The treatment has been initiated, and it has been considered that it would be appropriate to evaluate him for hyperactivity disorder according to the response he would give to the treatment. For treatment sertraline 75 mg/day and diazepam 5 mg/day have been prescribed, and the patient’s depressive complaints and suicidal thoughts have gradually disappeared during the monitoring period. His irritability and emotional state şuctuations have also been reduced. The patient had been on levetiracetam 1000 mg/day, carbamazepine 800 mg/day, valproate 1000 mg/day. Insertion of a VNS (Vagal Nerve Stimulator) and a detailed psychiatric re-examination afterwards have been planned. The literature suggests that neuropsychiatric symptoms such as ataxia, epileptic seizures, impairment in cognitive functions, behavioral and compliance problems were observed in children diagnosed with Encephalitis. In parallel with the literature, our patient has had significant problems that disrupted his academic success and social compliance after the disorder, even though he had no cognitive or behavioral problems prior to the disorder, based on the detailed story and information received from the family, school scales and the patient’s academic and behavioral records kept at school. In the context of this case, the importance of neuropsychiatric evaluation after central nervous system infections is manifested once again.