Psychiatry and Clinical Psychopharmacology
Case Report

Sertraline-Induced Leukocytoclastic Vasculitis with Definite Causal Association: A Case Report


Department of Psychiatry, Muğla Sıtkı Koçman University, Faculty of Medicine, Menteşe, Muğla

Psychiatry and Clinical Psychopharmacology 2023; 33: 218-221
DOI: 10.5152/pcp.2023.23712
Read: 348 Downloads: 221 Published: 07 August 2023

Antidepressants like sertraline are frequently used to treat psychiatric diseases like depression, panic disorder, and obsessive-compulsive disorder. Small-vessel vasculitis called leukocytoclastic vasculitis is defined histopathologically by immune complex-mediated vasculitis of the dermal capillaries and venules. Typically, it shows up as purpura on the lower extremities, either with or without systemic involvement. Leukocytoclastic vasculitis can be idiopathic but it can also happen in conjunction with several medications. Here, we present data on sertraline-induced leukocytoclastic vasculitis in a patient with major depressive disorder. To our knowledge, sertraline and other selective serotonin reuptake inhibitors have not previously been definitively linked to leukocytoclastic vasculitis, which is rare with antidepressants.

Cite this article as: Selçuk M. Sertraline-induced leukocytoclastic vasculitis with definite causal association: A case report. Psychiatry Clin Psychopharmacol. 2023;33(3):218-221.

EISSN 2475-0581