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Objective: Our aim is to determine whether the serum prolidase levels are associated with the etiopathogenesis of schizophrenia.
Methods: This study included 30 patients with schizophrenia, who were consecutively recruited from psychiatry outpatient clinics at the university hospital and 30 healthy individuals recruited from community. Each patient underwent a detailed diagnostic evaluation by psychiatry residents by using The Structured Clinical Interviews for DSM-IV (SCID-I). Serum prolidase activity and oxidative parameters was measured in patient and control groups. The severity of psychotic symptoms was assessed using the positive and negative syndrome scale (PANSS).
Results: Serum prolidase level was significantly higher in schizophrenia patients compared to healthy subjects (p<0.001). Oxidative stress parameters were found significantly difference between schizophrenia patients and healthy subjects. Serum prolidase level did not show any correlation with markers of oxidative stress in patients.
Conclusion: Prolidase activity, glutamate transmission and oxidative stress may be inter-related in the etio-pathogenesis of schizophrenia.