Delusional parasitosis which is also known as Ekbom syndrome is a very rare psychological disorder. This disorder is characterized by patient, who has a static and false belief of having his or her body being covered by insects. This delusion is persistent even though no scientific evidence can be found. The disorder is divided as primary or secondary according to etiology, primary being classified under somatic type delusional disorders. The secondary reasons that may cause delusional parasitosis include psychological disorders like dementia, psychosis, schizophrenia, obsessive compulsive disorder, bipolar disorder as well as organic disorders like DM, HT, CVD, vitamin deficiencies and endocrine disorders. Even though delusional parasitosis is a psychiatric disorder, which is treated with atypical and typical anti-psychotics, at doses being lower than those used in schizophrenia, patients usually refer to family practitioners, internal medicine specialists and dermatologists. As these patients have weak insight, it may be hard referring them to a psychiatrist that leads to elevated costs because of unnecessary laboratory examinations and improper treatment as well as grievances of the patient and relatives. This paper is a report of a patient with secondary/secondary functional delusional parasitosis, who also has DM and HT with ongoing depressive episodes with anxiety. The object of the paper is to review the clinic, etiology and treatment of Ekbom syndrome, which is a rare disease that may accompany organic disorders.