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Schizophrenia and obsessive compulsive disorder (OCD) the relationship between has attracted the attention of physicians for many years. Several studies suggest increased prevalence-rates of obsessive-compulsive symptoms (OCS) and even of Obsessive compulsive disorder (OCD) in patients with schizophrenic disorders. 10-52% of obsessive-compulsive symptoms and 7.8 - 26% of OCD rate in patients with schizophrenia reported. The research on comorbidity between OCD and schizophrenia: On one hand, it is argued that high prevalence of comorbidity has implied common risk factors (neuroanatomical and neuropsychological correlates) and a causal relationship between these mental illnesses. Generally the dopamine system in schizophrenia and the serotonin system in OCD is considered to play a major role.In clinical practice improvement of obsessive-compulsive symptoms with serotonergic agents that neurochemical disturbances in the serotonin system in OCD have suggested. The case is a 22 year old male, single, high school graduate, unemployed, who lives with his family. The patient was admitted with complaints of often bathing, staying too long in the bathroom and toilet. In the past, he had been admitted to various institutions buthe did not benefit from treatment. Three months ago, he has not been cleaned sufficiently with the idea of a knitting needle stuck into the anus in the toilet and rectum was wounded. Patient was taken to the emergency hospital by his family and operated. In this study, a OCD patient with schizo-obsessive disorder who has been a non-responder to antidepressants for the last two years but whose symptoms improved after the addition of amisulpride 200 mg/d, is presented in the light of the literature examining in the framework of the history of disease The role of dopamine in OCD is not well known. Serotonin-dopamine receptor antagonists and dopamine receptor antagonists to treat refractory OCD successfully showed the role of the dopaminergic system in the pathophysiology of OCD . Two of these neurotransmitter systems are known to interact with each other. Obsessive compulsive disorder is still considered primarily an anxiety disorder, though historically there has always been a question of whether obsessive-compulsive symptoms might be more properly considered as psychotic in nature, the so-called schizo-obsessive disorder, or as subtype.