Psychiatry and Clinical Psychopharmacology

Rapid-onset hyponatremia induced by duloxetine in a middle-aged male with depression and somatic symptoms

Psychiatry and Clinical Psychopharmacology 2011; 21: -
Read: 594 Published: 22 March 2021

Duloxetine is a relatively balanced selective serotonin and noradrenaline reuptake inhibitor. We report a case of hyponatremia induced by duloxetine that developed rapidly after starting the medication in a middle-aged male with multiple somatic symptoms and depression. Two days after discontinuation of duloxetine and management with hypertonic saline as well as şuid restriction, the serum sodium level normalized. The patient had two risk factors for developing hyponatremia, namely severe weight loss and pneumonia. Therefore, when treating patients with depression and somatic symptoms, especially with risk factors for developing hyponatremia, close monitoring for clinical and laboratory evidence of hyponatremia may be essential.

EISSN 2475-0581