Psychiatry and Clinical Psychopharmacology
Original Article

Quantitative EEG Differences in Subtypes of Frontotemporal Dementia

1.

Uskudar University, NPIstanbul Brain Hospital, Department of Neurology, Umraniye, Istanbul, Turkey

2.

Uskudar University, Faculty of Humanities and Social Sciences, Department of Psychology, Umraniye, Istanbul, Turkey

3.

Yeditepe University, Faculty of Arts and Science, Department of Psychology, Atasehir, Istanbul, Turkey

4.

Uskudar University, Faculty of Medicine, Department of Neurology, Umraniye, Istanbul, Turkey

Psychiatry and Clinical Psychopharmacology 2020; 30: 182-185
DOI: 10.5455/PCP.20200215073554
Read: 546 Downloads: 206 Published: 19 January 2021

Background: Frontotemporal dementia (FTD) is the second most common group of neurodegenerative disorder following Alzheimer’s Disease (AD); and characterized by degeneration of frontal and/ or temporal lobes. FTD can be classified as behavioral variant FTD (bvFTD) and primary progressive aphasia (PPA). The aim of this study is to investigate electrophysiological differences in bvFTD and nonfluent/agrammatic PPA (naPPA), one of three forms of PPA.

Methods: Twelve patients with bvFTD and 15 patients with naPPA were included in the study. EEG was recorded from 19 electrode sites based on international 10-20 system. Each participant’s data were averaged across the recording epochs for each electrode, and the mean absolute power values were computed for delta, theta, beta and alpha frequency bands.

Results: For all frequency bands, inter-hemispheric and intrahemispheric coherence were calculated. In absolute power; increased theta power at all regions was found in naPPA group as compared to bvFTD group. Regarding coherence; increased alpha coherence at inter-hemispheric frontal region was found in bvFTD as compared to naPPA group.

Conclusions: Our findings suggest that subtypes of FTD vary in resting-state EEG especially indexed by the decreased theta power reflecting bvFTD.

To cite this article: Salcini C, Cebi M, Sari AB, Tanridag O, Turhan N. Quantitative EEG Differences in Subtypes of Frontotemporal Dementia. Psychiatry and Clinical Psychopharmacology 2020;30(2):182-185

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