Background: Frontotemporal dementia (FTD) is the second most common group of neurodegenerative disorder following Alzheimer’s Disease (AD); and characterized by degeneration of frontal and/ or temporal lobes. FTD can be classified as behavioral variant FTD (bvFTD) and primary progressive aphasia (PPA). The aim of this study is to investigate electrophysiological differences in bvFTD and nonfluent/agrammatic PPA (naPPA), one of three forms of PPA.
Methods: Twelve patients with bvFTD and 15 patients with naPPA were included in the study. EEG was recorded from 19 electrode sites based on international 10-20 system. Each participant’s data were averaged across the recording epochs for each electrode, and the mean absolute power values were computed for delta, theta, beta and alpha frequency bands.
Results: For all frequency bands, inter-hemispheric and intrahemispheric coherence were calculated. In absolute power; increased theta power at all regions was found in naPPA group as compared to bvFTD group. Regarding coherence; increased alpha coherence at inter-hemispheric frontal region was found in bvFTD as compared to naPPA group.
Conclusions: Our findings suggest that subtypes of FTD vary in resting-state EEG especially indexed by the decreased theta power reflecting bvFTD.
To cite this article: Salcini C, Cebi M, Sari AB, Tanridag O, Turhan N. Quantitative EEG Differences in Subtypes of Frontotemporal Dementia. Psychiatry and Clinical Psychopharmacology 2020;30(2):182-185