Behçet’s disease is a recurrent inşammatory disorder involving multisystem of the body. The classical triad of Behçet’s disease are recurrent oral and genital ulcers and uveit. Neurological symptoms are observed as initiation of symptom only on three percent(%3) of cases. The clinical aspect of disease is often like Neuro-Behçet Syndrome with focal neurological signs.. In our case, 25-years-old man patient with schizophrenia that using clozapine is observed after diagnosed Behçet’s disease in 6 month. Colchicine is used in this period at the same time. We observed the using of combined clozapine-colchicine,without developing agranulocytosis or other severe adverse side effects during a 6-mounth follow-up. We used to total blood count.There were not any blood parameters in abnormal range during 6 month The initiation of Behçet’s disease can be only with the psychiatric symptoms This can cause inaccurate diagnosis and treatment(2).Neuropsychiatric symptoms, like psychosis and depression,often occur in Behçet’s disease. The safety and efficacy of combined clozapine-azathioprine treatment is researched,previously. But the safety and efficacy of combined clozapine-colchicine treatment have never been assessed.