Priapism is a state of prolonged and unwanted erection, which is not associated with sexual stimulation or sexual desire. Priapism may occur in many medical diseases or as a side effect of certain medications. Immediate diagnosis and treatment is essential for priapism, because ischemia of cavernous tissues would result in erectile dysfunction. In this article, we report a 12-year-old male patient who has priapism associated with the addition of risperidone on methylphenidate monotherapy. After drug therapy was discontinued and the implementation of the cavernous drainage, priapism drew back and disappeared. This is the first report of priapism associated with the addition of risperidone on methylphenidate monotherapy in literature, to our knowledge. This issue entails to get attention that these two psychopharmacologic agents, which are often used concomitantly, could lead to priapism.