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Peripheral edema is often associated with medical etiologies (cirrhosis, heart failure, protein deficiency, cancer, renal diseases) and drugs (NSAID, steroids, antihypertensives and immunosuppressive drugs). It is less seen side effect of psychotropic drugs. There are reports of peripheral edema during treatment with escitalopram, olanzapine, olanzapine-mirtazapine combination, trazadone, quetiapine and risperidone. The recent increase in the number of cases of edema occurring during antidepressant and antipsychotic treatment indicates that this possible complication is not rare. Here, for the first time in the literature, we report a case of female patient, who developed peripheral edema after sertraline-olanzapine combination use. A 20-year-old female patient applied with acute psychosis. She had delusions of getting pregnant and having pains of childbirth. She was prescribed olanzapine 10 mg once a day. One month later, she was admitted with post-psychotic depression and sertraline 50 mg is added on olanzapine. 2 months after starting the combination of olanzapine and sertraline, peripheral edema, that is bilateral in both legs and hands, developed. Sertraline treatment was discontinued. Within 2 days after sertraline was stopped, peripheral edema completely disappeared. Thyroid, renal, liver function tests, urinalysis results, serum sodium, chlorine, protein and albumin levels, infection markers were all within the reference range. Edema has been reported during treatment with a number of psychotropic medications. There has been so far no case report regarding olanzapine sertraline combination-related peripheral edema. Our case report suggests that clinicians should be aware of rare occurrance of peripheral edema when treating patients, especially with combination therapies such as sertraline and olanzapine that may not occur in the early stage of treatment.