Side effects of drugs used in psychiatry has been a subject of debate. This issue is to be discussed after use of atypical antipsychotics. Long-term use of atypical antipsychotics and some antidepressants may lead to especially deterioration of glucose homeostasis and side effects such as weight gain. Case: The patient, a 42-year-old female applied to our out-patient clinic with severe anxiety and restlessness. There were no pathological findings on physical and neurological examination. Biochemical tests were within normal limits. Generalized Anxiety Disorder was diagnosed according to the DSM IV TR. Fluoxetine 20mg/day treatment was initiated. Sweating, trembling, palpitations and hunger attacks were detected at the examination after two weeks. Upon consultation in the Internal Medicine Clinic, impaired glucose tolerance was determined. Fluoxetine treatment was stopped and citalopram 20 mg/day was initiated. The patient’s psychiatry symptoms were decreased while some other physical symptoms were setting on. In the same day, fasting blood glucose was 122 mg/dl thus citalopram treatment was stopped. Sertraline 50 mg/day was started. One month after starting with sertraline, both psychiatric symptoms and biochemical tests regressed. There are conşicting results that antidepressants increase the risk of diabetes mellitus. As in this case, disorders of glucose metabolism occurs after the use of different antidepressant, suggesting that individual genetic variations in drug metabolism is important.