Case: A 17-years old girl presented to emergency department with spasm at neck and upwards shifting in her eyes. The patient who presented to emergency department later in the evening at the same day was given 0.04 mg/kg biperiden and admitted to hospital for further follow-up. In her detailed anamnesis, it was found she had been using sertraline over one year with a diagnosis of major depression. She reported that she had taken four pills including 50 mg sertraline 2 days before presentation, as she felt bad. During follow-up, biperiden administration was repeated as the spasm at neck and shifting in eyes were recurred; after biperiden administration, it was observed that contraction was regressed. It was recommended to maintain current therapy. The patient with a good health status who had no dystonia during follow-up was discharged by the recommendation of follow-up in pediatric psychiatry.
Discussion: Movement disorder due to use of selective serotonin reuptake inhibitor is a rare adverse event. It occurs lower than 1 per 1000 patients using SSRI. Dystonic reactions related to antidepressants can onset within hours to several weeks after dose escalation. Antidepressant-related EPS adverse events aren’t dose depended and can occur by both short- and long-term use. There was a long-term antidepressant use in our patient. The dystonia developed 2 days after acute dose escalation. Dystonia was manifested as oculogyric crisis and spasm at neck. Given the patient had no comorbid disease and normal laboratory evaluations, it was suggested that the condition was related to drug use. We presented this case as it is rarely encountered in the literature.