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Sleep disorders include a wide range of disorders that impair health and quality of life. Clinicians must efficiently identity individuals with sleep disorders and direct effective treatment. Management requires the identification and treatment of the underline medical and psychiatric disorder. We recognize that sleep disruption may exacerbate symptoms of other diseases. Neurologic disorders, cardiovascular disease, pulmonary disease, chronic kidney disease gastrointestinal conditions, endocrine conditions have been associated with poor sleep. Parkinson Disorder (PD):As many as 60% patients with PD suffer from insomnia, 15%-59% from REM sleep behavior disorder (RBD) and 30% four excessive daytime sleepiness (1). Unlimited trial of zolpidem, clozapine, quietapine has shown a benefit on insomnia in PD. Clonazepam and melatonin is effective in RBD cases. Modafinil is well tolerated in sleepiness patient. Restless legs syndrome (RLS) and periodic limb movement: These disorders have a major impact on nocturnal sleep and daytime functioning. Treatment of sleep complaint is concerned four categories; Dopaminergic agents, opioids, anticonvulsants and benzodiazepines. Alzheimer’s disease and other dementias: Sleep is usually more fragmented, slow-wave sleep is decreased and REM sleep may be reduced. Trazodone, quetiapine, zolpidem for the insomnia, modafinil for the excessive daytime sleepiness, Donepezil, atypical antipsychotics and anticonvulsants for the nocturnal agitation may be considered. Neurologic conditions with extensive brain damage such as multiple sclerosis, traumatic brain injury, and infectious encephalitis can extensively alter sleep-wake schedules and sleep stages. Clinicians must efficiently effective treatment in individuals with sleep complaint. Asthma and Chronic Obstructive Pulmonary Disease (COPD): Nocturnal cough, wheeze and breathlessness are problems for sleep. Treatment is by optimizing inhaled steroids and beta agonists. Patients with COPD exhibit Oxyhemoglobin desideration alluring sleep especially during REM sleep, which produces greater alveolar hypoventilation in COPD. The treatment choice is oxygen therapy. Cardiovascular Disorders (CD): CD is very common, affecting 26% of the population (3). American population one of the most significant recent developments in the field has been the recognition that sleep disorders such as sleep apnea can cause or worsen CD and further more that CD can cause sleep disorders. Treatment of obstructive sleep apnea must be with nasal continuous positive airway pressure (CPAP) devices and avoidance of benzodiazepines, alcoholic beverages. Cancer patients: Fatigue is a major complaint in patients with cancer, one hypothesis is that some of the cancer related fatigue may be related to disturbed sleep or to disturbed sleep- wake rhythms(4). Pharmacologic treatment (e.g., sedative-hypnotics for insomnia psychostimulants for fatigue) and psychological treatments (e.g., activity-based interventions, and bright light therapy) may be considered. Fibromyalgia And Chronic Fatigue Syndromes (CFS): These patients present with persistent tiredness or physical fatigue accompanied by unrefreshing sleep. Traditional hypnotic agents do not provide restorative sleep or reduce pain. Two recently approved medications for the treatment of fibromyalgia are the SNRI duloxetine and the neuromodulator agent pregabalin. Nonspecific treatments of patient with fibromiyalgia include behavioral approaches to improve sleep hygiene. Endocrine Disorders: (ED): Sleep disorders, particularly sleep apnea, are common in many endocrine conditions. Androgens appear to exacerbate sleep apnea. Hypothyroidsm is a risk factor for sleep related disorders. Some evidence supports a role of sleep disorders in the pathogeneses of metabolic disturbances associated with obesity. Management requires treatment of the underline endocrine dysregulation and CPAP therapy in patient with sleep apnea. Gastrointestinal Disorder (GD): Sleep disturbance has been described as a common occurrence in patients with gastroesophagial reşux disease (GERD) and irritable bowel syndrome (IBS). Powerful acid suppression is the most common treatment for GERD. Studies have documented that sedating drugs prolong clearance during sleep at GERD and IBS. Chronic Kidney Disease (CKD): A significant percentage of passions with CKD report hypersomnolance, insomnia, snoring and witnessed apneas. Sleep apnea may be treated with CPAP devices or with a change in the type of dialysis. One approach to managing insomnia in CKD is to optimize sleep hygiene and use hypnotics. As a result, the basic treatment of sleep disorders in chronic physical diseases, to treat an underlying chronic disease, sleep hygiene, organizing and editing will be provided with the appropriate medical treatment.