Bipolar disorder is a disease typically starts at adolescence and early adulthood, namely reproductive period. Thus, the treatment of women at reproductive period is very important because of the teratogenic effects of psychotropic drugs. It is informed that use of classical antipsychotics in the course of pregnancy was not associated with congenital malformation and birth weight. While all drugs are transferred to placenta, among antipsychotics quetiapine is the least transported one. Animal studies have not showed any teratogenic effect. Even though human studies about the embryonic/fetal risk assessment are very limited, recent studies have shown no increased risk of birth defect in quetiapine-exposed newborns and when compared to others, quetiapine can be a safe option in pregnancy. In this report, on the treatment of quetiapine, there were not any teratogenicity and perinatal complication in four pregnant women, who have bipolar disorder in depressive or manic episode.