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Background: To investigate the current status of anxiety and depression symptoms in patients with
brain glioma and identify the risk factors associated with anxiety and depression symptoms.
Methods: A total of 105 patients diagnosed with glioma at Longgang Central Hospital of Shenzhen
from January 2021 to April 2024 were included in this study. The Hospital Anxiety and Depression
Scale (HADS) was used to assess the anxiety and depression symptoms of the patients, who were then
grouped based on their scores. Chi-square tests and binary logistic regression analyses were performed
to identify the independent risk factors for anxiety and depression symptoms in glioma patients.
Results: The average HADS-Anxiety score among glioma patients was 8.72 ± 3.41, with an anxiety
symptoms prevalence of 61.90% (65/105). The average HADS-Depression score was 7.73 ± 2.91, with
a depression symptoms prevalence of 55.24% (58/105). Among them, 58 patients (55.24%) had both
anxiety and depression symptoms, seven patients (6.67%) had only anxiety symptoms, and 40 patients
(38.10%) had neither anxiety nor depression. The results of binary tic regression analysis showed that
family monthly income, seizures, sleep quality, and cognitive function impairment were independent
risk factors for anxiety and depression symptoms (P < .05). Marital status was an independent risk
factor for depression symptoms (P < .05).
Conclusion: Glioma patients exhibit a high incidence of anxiety and depression symptoms. The
occurrence of these conditions is significantly associated with lower monthly household income,
seizure occurrence, sleep disturbances, and cognitive impairment.
Cite this article as: Zheng X, Zhang W, Li Y, et al. Prevalence and independent risk factors of anxiety and depression symptoms in glioma patients: A cross-sectional analysis. Psychiatry Clin Psychopharmacol. Published online April 18, 2025. doi 10.5152/pcp.2025.241021.