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Paroxetine is a selective serotonin reuptake inhibitor (SSRI), with antidepressant and anxiolytic characteristics. In association with paroxetine cessation, certain side effects can be observed frequently, including dizziness, vertigo, nausea, vomiting, headache, anxiety, insomnia, and irritability. Paroxetine-induced peripheral edema has been reported. However, there has been no report on peripheral edema related to paroxetine cessation. Here, we report a case who developed peripheral edema related to paroxetine discontinuation and whose peripheral edema disappeared after resumption of the paroxetine treatment.