Paroxetine is a selective serotonin reuptake inhibitor (SSRI), with antidepressant and anxiolytic characteristics. It can be frequently observed some side effects, associated with paroxetine cessation such as dizziness, vertigo, nausea, vomiting, anxiety, insomnia and irritability. Paroxetine induced peripheral edema has been reported. However, there has been no report on peripheral edema related to paroxetine cessation. Here, we report a case, which developed peripheral edema related to paroxetine discontinuation and whose peripheral edema was disappeared after beginning of the paroxetine treatment.