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Bupropion HCl, is a second-generation-antidepressant, a dopamine-noradrenaline reuptake-inhibitor, has two forms; extended-release (ER) and slow-release (SR). Its’ positive features are that having little side-effects like sexual-dysfunction, weight-gain and attention-deficit. But bupropion may lower the epileptic seizure threshold. The seizure risk was reported to be associated with the peak level, peak numbers and doses due to SR-form. In the literature epileptic-seizure due to the form of bupropion-SR is rare; there are some case reports with generalized tonic clonic seizures. In this article an epileptic case report that occurred with spontaneous orgasm with bupropion-SR form is presented. RA is a 67-year-old-married female, who applied to psychiatry outpatient clinic with symptoms of generalized anxiety disorder; she has been treated with sertraline 100 mg/day and alprazolam as needed. Sertraline and alprazolam doses were lowered by half. Venlafaxine and quetiapine were started and in a month time venlafaxine dose was increased to 150 mg/day while quetiapine to 100 mg/day. She was in remission and after one year, quetiapine was stopped because of the patient’s complaints like sedation, weight-gain. Due to permanence of her symptoms, venlafaxine’s dosage was decreased to 75 mg/day and bupropion HCL-SR was added on the treatment. A month later, venlafaxine was stopped and bupropion-SR, increased to 300 mg/day. It reduced the patient’s complaints. In the third month of the treatment, the patient reported orgasm at any episodes of the sleep without dreams about sexuality or stimulation, every night. EEG was taken with the prediagnosis of ictal orgasm. There were “slow-wave activity in both frontal lobes and sharp-slow-wave in the left temporal lobe. The result was possibly a frontal seizure and bupropion HCL-SR was stopped. The brain-MRI findings were normal. In a month the frequency of her spontaneous orgasm decreased to two in a week and disappeared in three months. There wasn’t epileptiform activity in control EEG findings. The ictal-orgasms in female patients were reported in literature were usually epileptic and there were sharp-wave-spike complexes in parietal and temporal regions. Epileptic-seizure is one of the serious side-effects of drugs. Bupropion usage is contraindicated in the patients using MAOIs and in when there is anorexia, bulimia, head injury and a family history of epilepsy. Epilepsy cases due to the use of bupropion-SR are often in generalized- tonic-clonic form. To our knowledge, the case is the first about ictal orgasm induced by bupropion-SR. The case took our attention with these features: no history of epilepsy or a cause of predisposition to epilepsy, the occurrence of seizure after using bupropion-SR 300 mg/ per day, epileptiform activity in EEG and with the recovery after stopping the drug. In cases which use Bupropion, seizures must be in consideration or when investigating the etiology of seizures, asking about the use of Bupropion is important.