Olanzapine treatment in choreoathetosis due to bilateral striopallidodentate calcinosis

Bilateral Idiopathic Striopallidodentate Calcinosis (BISPDCs) refers to idiopathic calcification of the basal ganglia and secondary striato-dentate calcinosis. Its definition comprises numerous metabolic abnormalities including disturbances of calcium and phosphorous metabolism. In this article, a case with BISPDCs secondary to hypoparathyroidism who presented with generalized choreoathetosis has been reported. A daily dose of 2.5 mg of olanzapine has been initiated and increased gradually up to doses 10 mg/daily. In six weeks time, the patient was almost free from choreoathetosis. Thus, olanzapine may be a good choice at the symptomatic treatment of choreoathetosis due to BISPDCs.