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Current literature points to hypofunction of the lprefrontal cortex in depression. Repetitive transcranial magnetic stimulation (rTMS) activates cortical neurons. In our case, we report a-53-year-old female patient with the diagnosis of depression. she was on various antidepressant medications for 3 years and her symptoms were partially remitted. After 10 sessions of rTMS, depression scores significantly improved. (Hamilton Depression Scores decreased from 20 at baseline to 4 after treatment). We questioned whether daily left prefrontal rTMS might improve mood in resistant depressed subjects and report a case that depression symptoms completely remitted for the first time in 3 years. Daily left prefrontal rTMS appears to be safe, well tolerated and may alleviate depression.