SLE (Systemic Lupus Eritamatosus) is a chronic and multisystemic autoimmune disease associated with different clinical symptoms. Involvement of the central nervous system by SLE causes neurologic and psychiatric manifestations (Bruns et al. 2006). These psychiatric problems include psychosis, mood disorder, anxiety and obsessive compulsive disorder (OCD). The most common psychiatric disorders are suffering major depression and anxiety disorder. Approximately 3/4 of female patients with SLE have at least one psychiatric disorder during their lifetime. The reasons for the high prevalence of psychiatric disorders in SLE patients are poorly understood. Potential explanations include the high doses of corticosteroids commonly used in SLE treatment, the psychological stress of having a major chronic systemic disease and autoimmune phenomena related to SLE itself, specifically autoantibodies against neuronal tissues. In this case report, a 24 years old female SLE patient with both mood disorder and OCD was presented. Her obsession was thinking about a man (i.e.. I must see M.) and compulsion was meeting with him. She exposed to sexual abuse because of her compulsions. She had also impulsive telephone calls and runaways from home, irritability. Her EEG and MRI was normal. We treated her with clomipramine 225 mg/day, olanzapine 10 mg/day successfully. We reported here a case of comorbid OCD and mood disorder as a rare manifestation of SLE.