.png)
Paroxetine is a selective serotonin reuptake inhibitor (SSRI), which has antidepressant and anxiolytic properties. Paroxetine is commonly seen side effects are nausea, headache, sedation, dry mouth, sexual dysfunction, sleep and constipation. Galactorrhea is a rare side effect in the use of paroxetine. This is the second report in our country about paroxetine-induced galactorrhea with normal serum prolactin level. A 33-year-old married woman with two children, who has depressive symptoms about 4 months used şuoxetine 40 mg/day on a regular medical treatment 2 months but complaints did not decline in therefore şuoxetine was ceased, paroxetine 20 mg/day was started as medical treatment. Patient admitted again to psychiatric clinic starting on the seventh day of paroxetine treatment and continued for five days with chest pain, şowing milk from both breasts. The patient was not taking another medication. For the first time in history it was noted that this complaint. There were no abnormalities in complete blood count, blood biochemical tests, thyroid function tests, prolactin (18.29 ng/ml, N: 3.34 - 7.26) and other pituitary hormones. Breast ultrasound and magnetic resonance imaging of the hypothalamic/pituitary area were normal. The galactorrhea ceased approximately 1 week after the discontinuation of paroxetine, at which time she was restarted on escitalopram 10 mg/day. She was maintained on escitalopram 10 mg/day for the next 6 months without a recurrence of galactorrhea and with a remission of her depression. In case reports, antidepressant-induced galactorrhea with high or normal prolactin level was found. The probable etiologic mechanism increased of serum prolactin level mediated by serotonergic activation or mediated by serotonergic inhibition of prolactin inhibitor factors such as dopamine as antidepressant administration. TRH hypersensitivity has been suggested to be responsible for galactorrhea with normal serum prolactin level. Consequently, further studies are needed for the understanding of the mechanisms behind SSRI induced galactorrhea.