Leg oedema due to low-dose risperidone during maintenance monotherapy of schizophrenia

Drug-related peripheral leg oedema is most commonly associated with steroids, nonsteroidal anti-inflammatory, antihypertensives, and immunosuppressive agents. The second-generation antipsychotic risperidone is rarely associated with such oedematous complications. This adverse effect of risperidone occurs with a higher incidence in higher doses according to its dose-dependent nature. In this paper, a rare case of small maintenance dose risperidoneinduced peripheral leg oedema in a schizophrenia patient was reported.