Objective: To determine whether presence of an inşammatory state by using values of Neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) in manic patients.
Methods: This retrospective study was performed on 76 acute mania patients admitted to the inpatients psychiatry clinic of university hospital of Afyonkarahisar in Turkey. Diagnoses were based on Diagnostic and Statistical Manuel of Mental disorder (DSM-IV). The control group consisted of 74 healthy individuals recruited from the community. They were age- and sex- matched with the study group.
Results: The mean NLR value of patients was 2.2±1.4, and 1.6±0.5 for control group. The NLRs were significantly higher in patients with manic episodes (p=0.004) The MPV values of the manic patients were significantly lower than of the control group (10.0±1.2 vs. 10.9±2.3, p=0.027).
Conclusion: Inşammation may be a part of the complex pathophysiology of acute mania.