Non-steroidal anti-inşammatory drugs(NSAIDs) are very commonly prescribed and include a diverse group of medications like aspirin, indomethacin, naproxen, ibuprofen, ketoprofen, sulindac, diclofenac and many others used, in the treatment of pain syndrome. With this broad range of use, more knowledge is necessary on the risk of serious side effects in various categories of users of NSAID. Gastrointestinal, hepatic and renal side effects are the most common adverse reactions. In addition, NSAIDs frequently cause adverse effects on the central nervous system, include, for instance, confusion and ataxia with indomethacin however extrapyramidal reactions are reported rarely. Ibuprofen is the most common NSAID which is used for children, has shown to cause several side effects including extrapyramidal symptoms such as involuntary muscle spasm of face and neck. A 12-year-old girl applied to our hospital with oculogyric crisis, complaining of retrocollis with upward deviation of her eyes that seems to be acute dystonic reaction after using a single dose of ibuprofen for headache. There were no personal and familial histories. It was understood that the patient had been admitted to emergency service with the same complaints 16 hours ago and there were no important findings in physical and laboratory examinations. After IV biperidene injection, extrapyramidal symptoms disappeared.