Psychiatry and Clinical Psychopharmacology
Clinical Dilemmas in Psychopharmacology

High-dose antipsychotic medication; a practical pocket checklist

1.

Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada

2.

Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta Canada

3.

Neurochemical Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada

4.

Departments of Psychiatry and Clinical Pharmacology, University of Western Ontario, London, Ontario, Canada, IstanbulTurkey

5.

GATA Haydarpasa Training Hospital, Department of Psychiatry, IstanbulTurkey

Psychiatry and Clinical Psychopharmacology 2010; 20: 187-188
Read: 733 Downloads: 483 Published: 26 February 2021

There is evidence that a significant number of patients with schizophrenia and other chronic psychotic psychosis are prescribed high-dose antipsychotic drugs despite the fact that clinical guidelines recommend the routine use of a single antipsychotic drug in a standard dose. The prescriptions for high-dose and combined antipsychotic drugs are relatively common in clinical practice. This occurs despite the fact that results of published trials of high-dose antipsychotic drug treatment for schizophrenia provide little evidence to support effectiveness of using high-dose antipsychotic treatment and most importantly such strategy is not recommended. Moreover, there is mounting evidence of higher incidence of side effects and mortality associated with high dose antipsychotic treatment. Therefore we are presenting a practical pocket checklist which is aimed at minimizing predicted and unpredicted side effects during such treatments.


Yüksek doz antipsikotik ilaç tedavisi; pratik cep kontrol listesi

Klinik kılavuzlarda şizofreni ve diğer kronik psikotik psikoz hastalarında rutin olarak standart doz tek bir antipsikotik ilaç kullanımının önerilmesine rağmen, çoğu hastada antipsikotik ilaçların yüksek doz reçete edildiğine ilişkin kanıtlar vardır. Klinik pratikte yüksek doz ve kombine antipsikotik ilaç reçete edilmesi nispeten sık görülür. Yayınlanan çalışmaların sonuçlarında az kanıt olmasından dolayı yüksek doz antipsikotik ilaç tedavisi pek tavsiye edilmez. Ayrıca, yüksek doz antipsikotik tedavisinin yan etkileri ve mortalite oranı da yüksektir. Bu nedenle antipsikotik tedavi sırasında öngörülen ve öngörülmeyen yan etkileri asgariye indirmeyi amaçlayan pratik bir cep kontrol listesi sunuyoruz.

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EISSN 2475-0581