Hyperprolactinemia and galactorrhea are very common in psychiatric patients because of the mechanism of action of antipsychotic drugs on dopamine receptors. This side effect could also appear during antidepressant treatment. Hyperprolactinemia has been reported to occur as a side effect during treatment with different types of antidepressants including tricyclic antidepressants, selective noradrenaline reuptake inhibitors, selective serotonin reuptake inhibitors (SSRI). In some case reports this side effect has been linked with the dosage of the medication used. Besides, galactorrhea due to SRI usage has been proposed to be a result of direct stimulation of serotonin to prolactin release or indirect effect of serotonin as dopamine antagonist. In this paper we described a case that has been using escitalopram, sertraline, clomipramine at different times for the treatment of her Obsessive compulsive disorder. During her treatment with all three SRIs, she complained about galactorrhea and prolactin elevation. There was no pituitary adenoma determined by computer tomography and magnetic resonance imaging. OCD is a condition in which prevalence ranging from 1.9-3.3%, and the execution of extensive research on the biological origins. SRIs are the first choice in the initial stage of pharmacotherapy of obsessive compulsive disorder. A tricyclic serotonine reuptake inhibitor clomipramine and selective serotonine reuptake inhibitors şuoxetine, şuvoxamine, paroxetine, sertraline exist at this list. Clomipramine has more side effects due to its affinity on non-serotonergic receptors. İn addition as mostly used antiobsessional agent clomipramine is accepted as the most well-known drug regarding to antiobsessional effect. In our case various SRI’s are used with monotherapy at different times but; because of galactorrhea developed in the initial dose, pharmacotherapy could not be maintained effectively. İn this article; we purposed to discuss galactorrhea side effect of SRIs and resumption of treatment in OCD.