Psychiatry and Clinical Psychopharmacology
Review Article

Exploring the Complex Relationship Between Sleep, Depression and the Immune System


Marmara University, Department of Pharmacology and Psychopharmacology Research Unit, Istanbul, Turkey


Editor-In-Chief of Psychiatry and Clinical Psychopharmacology, Istanbul, Turkey

Psychiatry and Clinical Psychopharmacology 2020; 30: 449-457
DOI: 10.5455/PCP.20201207094228
Read: 889 Downloads: 539 Published: 20 January 2021

Sleeping has a critical function to promote health. Studies over the past ten years has documented that sleeping disorders has a strong influence on the risk of infectious diseases and in particular occurrence and progression associated with several major health issues including depression. Recent studies have focused on elucidating the underlying mechanisms that play a role in this situation. This article has been written to review the dynamics of sleep disturbance, sleep restriction, and insomnia on depression and the immune system. Also aimed to discuss the multi-faceted relationship that connect sleep disorder and immunity in terms of the neurobiology of sleep, inflammation and depression. In this context, what is known about the role of sleep on the immune system and the relationship between sleep disorder and depression and the immune system of depression will be reviewed.

To cite this article: Aricioglu F, Cetin M. Exploring the Complex Relationship Between Sleep, Depression and the Immune System. Psychiatry and Clinical Psychopharmacology 2020;30(4):449-457

EISSN 2475-0581