Masturbation can be seen in the normal course of development of children. Masturbation is common among young children. A prepubertal child with anxiety disorder, who developed excessive masturbation behavior during şuoxetine treatment is presented here, as a case report. A 5-year-old girl was admitted to our child and adolescent psychiatry outpatient clinic for fear of being behind a closed door and being alone in a room, frequently hand washing, being afraid of dogs and darkness, uneasiness, difficulty in falling asleep and nightmares. During the examination, she asked to keep the door open and she did not want to be apart from her mother. She seemed timid, spoke low voice and reluctantly. Her mood was anxious and could not been interviewed alone. There were not any diseases in her history. Family history revealed that her uncle was schizophrenia. She was diagnosed as having anxiety disorder according to DSM-IV. Fluoxetine 10 mg/day, was initiated for anxiety symptoms. Ten days after, her mother reported that her anxiety symptoms, nightmares and frequent hand washing decreased. However, masturbation was reported to be excessively increased. Her family said that it was publicly and listlessly. Her mother said that she masturbated three to five times daily, and each attempt continued for about 5–10 min. During şuoxetine treatment, she did not develop any other behavioral problems or hypomanic /manic symptoms. Because excessive masturbation developed after initiation of şuoxetine, the dose of şuoxetine was reduced as 5 mg/day. In the control examination after two weeks, her masturbation behaviors have been disappeared. Excessive masturbation behaviors in children have been reported following use methylphenidate risperidone, olanzapine and lithium. As we know excessive masturbation after şuoxetine not reported in the literature. The psychopathological relationship between excessive masturbation and şuoxetine treatment remains unclear. Clinicians treating children with şuoxetine should be aware of behavioral side effects, which may be alleviated by dosage reduction or possibly by starting with lower doses.