Psychiatry and Clinical Psychopharmacology

Dysphagia associated with aripiprazole dose increase in obsessive compulsive disorder

Psychiatry and Clinical Psychopharmacology 2014; 24: Supplement S154-S154
Read: 1502 Published: 18 February 2021

Dysphagia may occur as a side effect of neuroleptic treatment. Antipsychotics may have central and peripheral effects on swallowing due to depression of bulbus and dopaminergic and anticholinergic blockage. This is a rare case of dysphagia associated with aripiprazole dose increase. Our case is a 43-year-oldfemale patient, who is graduated from high school and married. She applied our psychiatry policlinic and she was diagnosed as having obsessive compulsive disorder. Fluoxetine 40 mg/day and aripiprazole 5 mg/day were started. Aripiprazole dose was increased one year later. After dose increase, dysphagia appeared. There was especially difficulty in swallowing solid foods. Aripiprazole dose was decreased to 5 mg/day. She has consulted with otorhinolaryngology and gastroenterology physicians. Dysphagia cannot be explained by organic pathology. One month later after dose decrease for aripiprazole, complaint about dysphagia was recessed. Extrapyramidal side effects and other movement disorders are rare in atypical antipsychotics so dysphagiais uncommon after aripiprazole which is partial agonist of D2 receptors and atypical antipsychotic. In literature, there is only one case about it. When there is a patient with swallowing difficulties, who is on an antipsychotic drug, we must consider drug-induced dysphagia.

EISSN 2475-0581