Mood disorders are one of the most prevalent psychiatric disorders in clinical practice. Etiology of mood disorders is still not clear. There are many hypotheses about this issue. One of them is endocrine pathologies and especially thyroid disorders. The association between mood disorders and thyroid functions came from; thyroid hormones are recommended in treatment resistant mood disorders, thyroid dysfunctions may lead mood symptoms, and mood stabilizers like lithium may have some side effects on thyroid hormones. In this presentation, I will summarize the relationship between thyroid and mood disorders in the lights of accumulating literature.