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Synthetic cannabinoids not being “herbal” or “natural” at all contain one or more representatives of several hundred different types of synthetic cannabinoids produced in laboratories. In the last few years, the use of synthetic drugs of abuse has grown, with little information available for healthcare providers about these drugs and how they act on patients using them. The use of synthetic cannabinoids is driven by several factors. After the introduction of new compounds, their use initially was not restricted by law. Moreover, their consumption cannot be verified by standard drug tests, which is particularly interesting for people going under regular drug testing. Easy access via the internet and affordability also contribute to the popularity of these drugs. Use of synthetic cannabinoids appeared in various types in our clinical experience. Our case, that we hope to contribute to this area, is 20 years old, single male, unemployed and has been using synthetic cannabinoids for nearly 1.5 years. He was hospitalized in our clinic, because of treating his family, aggressiveness, sleeplessness and talking to own self. One day after hospitalization, he became confused, agitated and he had visual hallucinations. In his laboratory examinations there was no pathology except high ACT levels, which is considered clinically significant by internal medicine consultation. There was also no pathology in the case of cranial MRI and neurological consultation. This situation was termed as delirium by synthetic cannabinoids acute intoxication and treated with antipsychotic, benzodiazepines and şuid replacement. On the fifth day of the treatment, place, person and time orientation was full and all psychotic symptoms disappeared. Using of synthetic cannabinoids was also confirmed by our case.