Melatonin is an indoleamine often used in children and adolescents. Melatonin is considered to be an effective clinical management for dyssomnias, sleep disorders present in children with attention-deficit hyperactivity, autism spectrum disorders, developmental delays. Quickacting capsules, controlled-release (CR) capsules, sublingual tablets and liquid forms are available. Melatonin is generally very well-tolerated in children and adolescents. The pharmacology, therapeutic applications, and side effects of melatonin are discussed.