Psychiatry and Clinical Psychopharmacology

Can miRNA Expression Levels Predict Treatment Resistance to Serotonin Reuptake Inhibitors in Patients with Obsessive-Compulsive Disorder?


Department of Psychiatry, University of Health Sciences, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey


Department of Medical Biology, University of Health Sciences of Medicine, İstanbul, Turkey


Department of Physiology, İstanbul Medeniyet University Faculty of Medicine, İstanbul, Turkey

Psychiatry and Clinical Psychopharmacology 2022; 32: 98-106
DOI: 10.5152/pcp.2022.22391
Read: 498 Downloads: 301 Published: 01 June 2022

Background: Obsessive-compulsive disorder is a psychiatric disorder with different clinical manifestations caused by the interaction of genetic and environmental factors. Recently, it has been shown that microRNAs play a role in the pathogenesis of some psychiatric diseases. We aimed to compare the expression levels of microRNAs between obsessive-compulsive disorder patients and healthy controls and investigate the association between miRNA expression levels and treatment resistance.

Methods: Twelve miRNA expression levels in venous blood of 100 obsessive-compulsive disorder patients and 50 healthy controls were detected by real-time polymerase chain reaction. Patients were assessed using the Hamilton Depression Rating Scale, Yale-Brown Obsessive-Compulsive Scale, and Yale-Brown Obsessive-Compulsive Symptom Checklist. Each patient was scheduled for a monthly follow-up for a minimum 6-month-period after serotonin receptor inhibitor treatments were initiated.

Results: We found that miR-26a-5p (P < .001), miR-21-3p (P < .001), miR-219a-1-3p (P = .016), miR- 106b-5p (P = .039), miR-6740-5p (P = .020), miR-320a (P = .001), miR-22-3p, and miR-16b-5p (P = .010) expression levels were statistically higher in obsessive-compulsive disorder patients than healthy controls; miR-135a-5p (P < .001) and miR-129-6b-5p (P < .001) expression levels were statistically lower. Also, it was determined that increased miR-106b-5p levels were associated with treatment- resistance (P = .020) and there was a negative correlation between miR-374b-3p and disease severity (P = .042).

Conclusion: In obsessive-compulsive disorder, there may be a potential value in the relationship between various miRNA expression levels and treatment resistance and disease severity, and future studies may be beneficial.

Cite this article as: Pirdoğan Aydın E, Alsaadoni H, Gökovalı Beğenen A, Özer ÖA, Karamustafalıoğlu KO, Pençe S. Can miRNA expression levels predict treatment resistance to serotonin reuptake inhibitors in patients with obsessive-compulsive disorder? Psychiatry Clin Psychopharmacol. 2022;32(2):98-106.

EISSN 2475-0581