Psychiatry and Clinical Psychopharmacology
Case Report

Augmented Reality 3MDR Therapy for the Treatment of PTSD and Comorbid Moral Injury: A Case Study

1.

Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States

2.

Military T raumatic Brain Injury Initiative, Uniformed Services University of the Health Sciences, Bethesda, United States

3.

The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, United States

4.

Warfighter Performance Department, Naval Health Research Center, San Diego, United States

5.

Leidos Inc, Reston, United States

6.

Department of Psychiatry, Leiden University Medical Center (LUMC), Leiden, the Netherlands

7.

Walter Reed National Military Medical Center, Bethesda, MD, United States

Psychiatry and Clinical Psychopharmacology 2025; 35: Supplement S160-S167
DOI: 10.5152/pcp.2025.24989
Read: 22 Downloads: 12 Published: 11 August 2025

Rates of veteran suicide, post-traumatic stress, and moral injury remain alarmingly high and continue to rise. While virtual reality and augmented reality technologies have shown promise in improving post- traumatic stress disorder (PTSD) severity, research on these innovative methods is still limited. Multi- modal memory desensitization and reconsolidation (3MDR), a cutting-edge therapy that combines Virtual Reality Exposure Therapy or Augmented Reality Exposure Therapy with a “walk and talk” therapy, has demonstrated significant potential in enhancing participant engagement and substantially reducing symptoms of PTSD and moral injury among combat veterans. This case study highlights the novel use of 3MDR with an augmented reality head-mounted display for treating combat-related PTSD and moral injury, offering a new perspective on addressing these critical issues.

Cite this article as: Raboy AL, Dehy JV, Bellini P, et al. Augmented reality 3MDR therapy for the treatment of PTSD and comorbid moral injury: A case study. Psychiatry Clin Psychopharmacol. 2025;35(Suppl. 1):S160-S167.

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