Psychiatry and Clinical Psychopharmacology
Original Article

Association of the Uncoupling Protein 2-866 G/A Polymorphism with Family History and Duration of Tobacco Use Disorder in a Turkish Population


Department of Psychiatry, Basaksehir Cam and Sakura City Hospital, İstanbul, Turkey


Department of Medical Biology, Istanbul University School of Medicine, İstanbul, Turkey


Department of Internal Medicine Division of Hematology, Gaziantep University, Gaziantep, Turkey


Department of Psychiatry, Psychiatry Clinic, Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, University of Health Sciences, Istanbul, Turkey

Psychiatry and Clinical Psychopharmacology 2021; 31: 280-285
DOI: 10.5152/pcp.2021.21526
Read: 964 Downloads: 423 Published: 23 September 2021

Background: A variety of substances cause neurotoxicity by increasing intracellular oxidative stress, followed by mitochondrial dysfunction. Uncoupling proteins (UCPs) act as membrane transport proteins and reduce reactive oxygen products and mitochondrial calcium influx. We aimed to study UCP2-866 G/A gene polymorphism in tobacco use disorder (TUD) by comparing genotype distributions between TUD patients and healthy controls considering clinical parameters.

Methods: One hundred eighteen patients with TUD and 96 healthy volunteers were included in the study. The diagnosis of the patients were then confirmed, based on the DSM-5 criteria. Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were used to determine UCP2 gene polymorphism.

Results: Our results demonstrated that the UCP2 genotype distribution and allele frequencies of the TUD patient group were significantly different from those of the control group. When the UCP2 genotype and the allele frequency distributions were compared between the two groups according to the family history of TUD in the patient group, the UCP2 genotype and allele frequency distributions were significantly different. The GG genotype or G allele percentage was significantly higher in patients with a family history of TUD, than the patients without a family history of TUD. Comparing clinical parameters based on the UCP2 genotype, the disorder’s duration was significantly different between the groups of UCP2 genotype. The duration of TUD was significantly shorter in patients with GG genotype than other genotypes.

Conclusions: In summary, the UCP2-866 G/A gene polymorphism might be associated with family history and duration of TUD in Turkish patients.

Cite this article as: Aytac HM, Pehlivan S, Kurnaz S, Pehlivan M, Cetinay Aydın P. Association of the uncoupling protein 2-866 G/A polymorphism with family history and duration of tobacco use disorder in a Turkish population. Psychiatr Clin Psychopharmacol. 2021;31(3):280-285.

EISSN 2475-0581