EISSN 2475-0581

IMPACT FACTOR: 0.5 INDEXED IN WEB OF SCIENCE

Psychiatry and Clinical Psychopharmacology

34 138 2024

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Evaluation of the Psychiatric Research Output From Turkey Via Web of Science Database: A Bibliometric Analysis

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High Doses of Second-Generation Long-Acting Antipsychotics in the Treatment of Patients with Severe Resistant Schizophrenia: A Six-Year Mirror-Image Study

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Video/Computer Game Addiction Among University Students in Ghana: Prevalence, Correlates and Effects of Some Demographic Factors

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Burnout, Job Satisfaction, and Psychological Symptoms Among Emergency Physicians During COVID-19 Outbreak: A Cross-Sectional Study

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Parental Attachment and the Theory of Mind Abilities as Predictors of Internet Addiction in Turkish Adolescents

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Investigating the Impact of the ECT on Thiol-Disulphide Homeostasis in Depressive Disorders

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Comparison of Drugs Prescribed by Psychiatrists and Child/Adolescent Psychiatrists

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Adaptation of Internet Gaming Cognition Scale to Turkish: Reliability and Validity Study

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Original Papers

Association of the Neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 Polymorphisms with Alcohol Dependence

Cem Sengul ¹ , Mehmet Emin Erdal ² , Ceyhan Balci Sengul¹ , Ozlem Izci Ay² , Ahmet Buber ³ , Huseyin Alacam ¹ , Mustafa Ertan Ay ² , Hasan Herken ¹

Author Affiliation(s)

1.

Pamukkale University, Faculty of Medicine, Department of Psychiatry, Denizli - Turkey

2.

Mersin University, Faculty of Medicine, Department of Medical Biology and Genetic, Mersin - Turkey

3.

Pamukkale University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Denizli - Turkey

Psychiatry and Clinical Psychopharmacology 2016; 26: 15-20

DOI: 10.5455/bcp.20151016123639

Keywords : alcohol dependence, neuropeptide Y, neurexin, polymorphism

Read: 910 Downloads: 585 Published: 21 January 2021

Volume 26, Issue 1, March 2016

Previous Article

Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects.

Methods: 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System.

Results: Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence.

Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction.

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