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Psychiatric disorders in children and adolescents have a high prevalence worldwide and are often associated with substantial psychosocial impairments. Most of these disorders have a high likelihood of persistence or recurrence of symptoms. More over these are risk factors for other psychiatric disorders in adulthood. Because of the potential risk of untreated psychiatric illnesses, several treatment approaches are developed and suggested for child and adolescent such as psychopharmacotherapy family intervention and psychotherapy etc. Psychotherapy can be a very effective tool for management of mental health disorders with children and adolescents, especially for parents and patients who may object to the use of pharmacotherapy. Physiological intolerance to medications, conditions resistant to medication such as emotional component or environmental cause for the child’s behavioral responses (e.g. family conşict) and parent’s suspicion for psychopharmacology are obstacles to prescribing medication in child and adolescent psychiatry. Psychotherapy is divided into modalities (e.g. individual, group, and family) and theoretical approaches (e.g. behavioral, cognitive, eclectic, existential, interpersonal, psychoanalytic, and psychodynamic). However, in this era of evidence-based medicine, only behavioral, cognitive–behavioral and interpersonal psychotherapies have large numbers of studies that meet the requirements to be called empirical studies. Evidence-based studies focus on the relative efficacy of treatments for specific subtypes of disorders and different intervention techniques for the same disorder. Studies revealed that evidence-based treatments for children and adolescents could be applicable to several diagnostic categories. Cognitive behavior therapy (CBT) is the most researched form of psychotherapy. It is revealed that CBT has significant effects on depression, anxiety, disruptive behavior problems, posttraumatic stress disorder (PTSD), and substance abuse in child and adolescents. Likewise, psychodynamic psychotherapy studies concluded that there were significant effects with all treatments such as conduct problems, anxiety disorders. Studies also investigated combined effects of psychopharmacologic and psychotherapeutic interventions. Empiric evidence supports that a combination of pharmacotherapy and psychotherapy is more beneficial to children and adolescents