Psychiatry and Clinical Psychopharmacology
Original Article

Antipsychotics With Different Chemical Structures Cause Different Degrees of Functional Impairments in the Primary Visual Cortex in a Murine Model: A Pilot Study


Department of Psychiatry and Microimaging Center, Wenzhou Seventh People’s Hospital, Wenzhou, Zhejiang Province, China


These authors contributed equally to this work and are co-first authors.


Department of Psychiatric-Neuroimaging-Genetics and Comorbidity Laboratory, Tianjin Anding Hospital, Tianjin, China


Department of Psychiatry, School of Mental Health, Jining Medical University, Jining, Shandong Province, China


Department of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, People’s Republic of China


Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China


MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, China


First Affiliated Hospital, Zhengzhou University, Zhengzhou, China


Henan Psychiatric Transformational Research Key Laboratory, Zhengzhou University, Zhengzhou, China


Canadian and Chinese Joint Laboratory of Biological Psychiatry, Xiamen Xianye Hospital, Xiamen, Fujian Province, China


Department of Psychiatry, The Fourth Center Hospital of Tianjin, Tianjin


Department of psychiatry, Tianjin Fourth Central Hospital, Tianjin, China


These authors are the co-corresponding authors.

Psychiatry and Clinical Psychopharmacology 2021; 31: 364-369
DOI: 10.5152/pcp.2021.20022
Read: 1989 Downloads: 631 Published: 13 October 2021

Objective: Antipsychotic medications can impair vision in patients with schizophrenia. However, little is known regarding the pharmacodynamics of antipsychotics in the primary visual cortex. We aimed to study the pharmacodynamics of antipsychotics in the visual cortex in a murine model.

Methods: We used an adapted 2-photon imaging technique to observe changes in calcium dynamics induced by 4 antipsychotics (olanzapine, risperidone, aripiprazole, and amisulpride) in the primary visual cortex of healthy and schizophrenic C57BL/6 mice. Visual function was further assessed by using a novel object recognition test.

Results: All 4 antipsychotics decreased calcium activity in the primary visual cortex and reduced visual recognition test scores in healthy and schizophrenic mice. The most potent drug was olanzapine, followed by risperidone, aripiprazole, and amisulpride. All drugs showed significant differences between groups.

Conclusion: Our pilot study demonstrated that antipsychotics impair visual cortical function. This finding underscores the importance of monitoring for visual adverse events in patients receiving antipsychotic medications to treat schizophrenia.

Cite this article as: Yu H, Ma X, Ji F, et al. Antipsychotics with different chemical structures cause different degrees of functional impairments in the primary visual cortex in a murine model: A pilot study. Psychiatr Clin Psychopharmacol. 2021;31(4):364-369.

EISSN 2475-0581