Psychiatry and Clinical Psychopharmacology
Review

An Overview of The Definition and Management of Treatment-Resistant Depression

1.

Departments of Psychiatry and Pharmacology, Dalhouise University, Halifax, NS, Canada

2.

Neuroscience and Psychiatry Unit, School of Psychiatry and Behavioural Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK

Psychiatry and Clinical Psychopharmacology 2002; 12: 92-101
Read: 688 Downloads: 431 Published: 09 March 2021

In this article, we review the literature defining treatment-resistant depression and pharmacological strategies to manage these difficult and challenging clinical cases. Augmentation strategies reviewed in this paper are limited and include the classic and very well-established antidepressant-augmenters such as lithium and thyroid, in addition to the newer use of pindolol and tryptophan. We also present possible clinical variables which may be complicating the choice, administration and monitoring safely and effectively during switching and augmenting antidepressant drugs.

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EISSN 2475-0581