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Tourette's disorder is a neuropsychiatric disease characterised by chronic vocal and motor tics that leads to severe psychosocial disability. Many old and new generation antipsyshotics had been used in the treatment of Tourette's Disorder, especially antipsychotics which have strong effects on D2 receptors. Amisulpride is an antipsychotic which has strong effects on D2 and D3 receptors. Parkinsonism, endocrine system side effects, and weight gain are less frequent than with the other antipsychotics. Amisulpride is safely used in the treatment of schizophrenia and the other psychoses in adults. In this case report we discuss amisulpride use in 3 cases with Tourette's disorder. These cases previously used other antipsychotics for Tourette's disorder treatment. Amisulpride was used at a dose of 75-200 mg/day. After treatment in all three of these cases, the Yale Global Tic Severity Scale score decreased.