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Tianeptine is an atypical antidepressant, which modestly enhances the mezolimbic release of dopamine. Tianeptine is an antidepressant that is accepted as not being abused by patients. However, there have been some case reports regarding abuse and/or addiction to it. The abuse of tianeptine is rare and so far has only been reported in patients with pre-existing multi substance abuse disorders. A total of 141 cases of abuse were reported between 1989 and 2004. The patients usually sought and experienced a psychostimulant effect. The stimulant effect of tianeptine has been specifically emphasized in some case reports of tianeptine abuse in the literature. In this poster, a twenty year-old female patient, who received tianeptine treatment for depression and developed tianeptine dependence is presented. In our case, the patient was taking sixty pills daily. Although she took sixty pills, her biological tolerance was excellent and hepatic and hematological parameters were not affected, similar to the findings of other reports in the literature. This case emphasizes that while prescribing tianeptine treatment clinicians should be careful using it in patients with substance abuse problems, as reported by other case reports in the literature.