Psychiatry and Clinical Psychopharmacology

A Closer Look at Familial Dysautonomia from a Social Communication Perspective: A Case Report and Review of Literature


Turkish Ministry of Health, Ağrı State Hospital, Child and Adolescent Psychiatry Unit, Ağrı, Turkey


University of Health Sciences, Erzurum Region Training and Research Hospital, Child and Adolescent Psychiatry Unit, Erzurum, Turkey


Department of Child and Adolescent Psychiatry, Atatürk University, School of Medicine, Erzurum, Turkey


Department of Child and Adolescent Psychiatry, University of Health Sciences, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey

Psychiatry and Clinical Psychopharmacology 2022; 32: 178-180
DOI: 10.5152/pcp.2022.21210
Read: 153 Downloads: 86 Published: 01 June 2022

Familial dysautonomia (Riley–Day syndrome) is a rare but fatal autosomal recessive peripheral neuropathy caused by a point mutation in I-κ-B kinase complex-associated protein gene. The disease, which affects primarily people of Ashkenazi Jewish origin, prejudices the development of primary sensory neurons determining the depletion of autonomic and sensory neurons. In this study, we report a 5-year-old girl with familial dysautonomia, and how her different psychiatric aspects may lead to genetic vulnerability. Obviously, the gene, the reason for this syndrome, and overreactions to different kinds of emotions, maybe a risk factor for having any mood disorders. From another perspective, this “genetic vulnerability” may be protective or related to the syndromes that affect social communication like autism.

Cite this article as: Turan B, Yitik Tonkaz G, Selcuk Esin I, Burak Dursun O. A closer look at familial dysautonomia from a social com- munication perspective: A case report and review of literature. Psychiatry Clin Psychopharmacol. 2022;32(2):178-180.

EISSN 2475-0581