Psychiatry and Clinical Psychopharmacology
Case Report

A Case of Chronic Schizophrenia Who were Switched from Combined Treatment to Monotherapy and Achieved a Decrease in Positive Symptoms after Lowering the Clozapine Dose

1.

Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Psychiatry Clinic, Ankara - Turkey

2.

Yildirim Beyazit University, School of Medicine, Department of Psychiatry, Ankara - Turkey

3.

Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Department of Psychiatry, Ankara - Turkey

Psychiatry and Clinical Psychopharmacology 2016; 26: 324-328
DOI: 10.5455/bcp.20130127023102
Read: 797 Downloads: 481 Published: 21 January 2021

A case of chronic schizophrenia who were switched from combined treatment to monotherapy and achieved a decrease in positive symptoms after lowering the clozapine dose Despite the limited evidence to support the combination of antipsychotics in treatment resistant schizophrenia in the literature, this situation is common in clinical practice. Treatment guidelines recommend monotherapy for schizophrenia primarily. In this article, a chronic schizophrenic case whose treatment is changed from combination of clozapine with aripiprazole to clozapine monotherapy and whose positive symptoms decreased with the decrease of clozapine doses 900 mg/day to 625 mg/day is reported.

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EISSN 2475-0581